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Moderate or severe hepatic impairment (Child-Pugh B or C), moderate or severe renal impairment (creatinine clearance less than 60 mL/minute), and patients concurrently using strong CYP2D6 inhibitors due to the risk of increased drug exposure and adverse reactions

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Linus Pauling Institute Oregon State University Updated in August 2021 by: Victoria J

The mechanism: KPV translocates into the cell nucleus and blocks the interaction between importin-alpha3 and the p65/RelA subunit of NF-kB, preventing p65 from reaching its transcriptional targets

Clinical trials evaluating semaglutide safety, including the SUSTAIN and STEP trial programs which enrolled thousands of participants, did not identify UTIs as a significant adverse event associated with the medication